Melnick-Needles Syndrome (MNS)

Melnick-Needles Syndrome (MNS) is characterized by skeletal development abnormalities such as malformations of the small bones in the ears, fingers, toes, ribs, joints, spine, and limbs. Characteristic facial features include very small chin, misaligned teeth, facial asymmetry, round cheeks, protruding brow ridges, and excess forehead hair growth. The other health problems include hearing loss, heart defects, and obstruction of the ureters. This rare congenital disorder is more lethal among males. This condition has no specific cure and the treatments are intended to manage symptoms. MNS was first described in 1966 by John C. Melnick and Carl F. Needles.